Genetic and functional characterization of the NanA sialidase from Clostridium chauvoei

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Genetic and functional characterization of the NanA sialidase from Clostridium chauvoei

Clostridium chauvoei is the causative agent of blackleg, a wide spread serious infection of cattle and sheep with high mortality. In this study we have analyzed the sialidase activity of the NanA protein of C. chauvoei and cloned the sialidase gene nanA. Sialidase is encoded as a precursor protein of 722 amino acids with a 26 amino acid signal peptide. The mature sialidase has a calculated mole...

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Production of toxins by Clostridium septicum and Clostridium chauvoei has been the subject of many conflicting reports. Roux and Chamberland (1887) first noted that 3 to 4 day filtrates were antigenic; conferring on guinea pigs an immunity against infection with viable organisms. Production of a lethal toxin by C. septicum was however, demonstrated by Leclainche (1898) and Leclainche and Morel ...

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ژورنال

عنوان ژورنال: Veterinary Research

سال: 2011

ISSN: 1297-9716

DOI: 10.1186/1297-9716-42-2